HGMD License Renewal

Concepts

• runcorn
• health services
• license management
• england
• supplier interest
• market engagementnhs england
• database of germline
• human genomic variants
• significant experience
• 2021interested suppliers

Location

United Kingdom:

Description

The requirement is for a comprehensive and searchable manually curated literature-based database of germline human genomic variants and their relationship with human disease, with links to associated peer reviewed scientific literature references and variant classification. The successful provider will demonstrate class leading and significant experience in the area, peer reviewed publications illustrating utility in the diagnostic setting and that their database is up to date and covers the breadth of the peer-reviewed scientific literature.

Total Quantity or Scope

The database must enable users to:1. Search extensively for rare and inherited disease associated variants;2. Search extensively for information relating to known variants associated with a particular disease;3. Search for gene and variant type, and specific variants, and link out to peer reviewed scientific literature;4. Have ease of accessibility and navigation of database pages;5. Download the database as a flat file with comprehensive variant annotation for integration into local bioinformatics pipelines that permits to link out to original scientific data sources.Pre-market EngagementNHS England & Improvement are currently undertaking an options appraisal and as part of this have issued a Notice to the market to gauge supplier interest and capability in relation to continuing the delivery of this service.Current thinking is that NHS England & Improvement will enter into a 36-month contract with an approximate total value of £2,200,000 exclusive of applicable VAT.Due to budget pressures expected to impact over the term, we expect for costs submitted to demonstrate a significant reduction upon the forecast, reflecting the stability offered by a three-year term.Please register your interest by 12pm 18/10/2021Interested suppliers should read the details in section VI.3 which specify further details about the requirement, how to register an interest in the possible procurement and the submission requirements for registering an interest. Additional information: 1. Suppliers are asked to describe, in detail, how their database meets EACH of the requirements numbered above. Each requirement is essential, and must be met in full. Suppliers may also choose to evidence how your database exceeds any, or all, of the requirements set out above.

CPV Codes

• 85100000 - Health services
• 48218000 - License management software package

Other Information

** PREVIEW NOTICE, please check Find a Tender for full details. ** Interested suppliers should register on the NHS England & Improvement e-procurement system here: https://health-family.force.com/login• Once logged in click 'Find Opportunities' and search for ‘HGMD License Renewal’• Click 'Register Interest' • Once you have registered your interest you will be able to view the Requirements and submit a response to the question within the portal (see Annex A for details).• Any messages about the opportunity should be sent via the e-procurement system. You can do this by going to the home page and:o Click on 'My proposals & Quotes' o Click the relevant Project Title o Click 'Messages' & 'New Message' The deadline for submitting Expressions of Interest is 12pm on 18/10/2021Submission Requirements on the Portal:Once registered via the e-Portal Atamis you will be able to submit responses to the following question to demonstrate your experience and capability to deliver the programme. QUESTION: Suppliers are asked to describe, in detail, how their database meets EACH of the requirements numbered below. Each requirement is essential and must be met in full. Suppliers may also choose to evidence how your database exceeds any, or all, of the requirements set out above.Requirements:- The database must enable users to:1. Search extensively for rare and inherited disease associated variants;2. Search extensively for information relating to known variants associated with a particular disease;3. Search for gene and variant type, and specific variants, and link out to peer reviewed scientific literature;4. Have ease of accessibility and navigation of database pages;5. Download the database as a flat file with comprehensive variant annotation for integration into local bioinformatics pipelines that permits to link out to original scientific data sources.