Purchase of SyncroPatch 384

Concepts

• cardiff
• syncropatch
• the nanion syncropatch
• the nanion syncropatch 384
• 384
• their research capabilities
• the medical discovery institute
• research
• medical
• institute

Location

Description

The Medical Discovery Institute have been allocated funding to purchase the Nanion SyncroPatch 384 to enhance their research capabilities.

Award Detail

CPV Codes

• None found

Legal Justification

MDI require 384-well automated patch-clamping with the following features: 1. Ability to patch in fluoride free solutions. This is critical as the channels we work on are affected by fluoride. 2. The ability to patch lysosomes. This is critical as we are investigating lysosomal channels and need to be able to patch them in their native membrane environment. 3. The ability to perfuse internal solutions during measurements. Critical to characterising channel function. 4. Is compatible with our existing Nanion port-a-patch and Patchliner devices to ensure consistency and allow protocols to be transferred between devices. 5. The ability to change to protocol on the fly for assay development. This equipment must adhere to the above criteria (including compatibility with existing equipment). Alternatives have been researched, however have been deemed incompatible. The only other high throughput electrophysiology system available is noted to be incompatible with MDI requirements. In addition to this, the supplier has a patent relating to the equipment, this being EP 1 775 586 81.

Other Information

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