Instrument to measure binding kinetics and thermodynamics parameters in individual cells in a high-throughput format

Concepts

• glasgow
• clinical chemistry system
• live cells
• individual cells
• eukaryotic cell types
• cellular binding interactions
• binding kinetics
• thermodynamics parameters
• a high-throughput format
• the binding properties

Location

Description

The Contracting Authority received funding to support a Glasgow-wide initiative that will enable users to measure the binding properties of molecules directly on live cells. To support this research, the Contracting Authority requires an instrument to measure binding kinetics and thermodynamics parameters in individual cells in a high-throughput format.

Total Quantity or Scope

The Contracting Authority has received funding to support a Glasgow-wide initiative that will enable users to measure the binding properties of molecules directly on live cells. The equipment will be suitable for a wide range of analyses for eukaryotic cell types and will be underpinned by support from dedicated research technical professionals within the Strathclyde Centre for Molecular Bioscience (University of Strathclyde) and the Integrated Protein Analysis Facility (University of Glasgow). The equipment will be part of the facility enabling the UK userbase integrated access to a breadth of bioanalytical and biophysical facilities to examine cellular binding interactions.

Award Detail

CPV Codes

• 33159000 - Clinical chemistry system

Legal Justification

The Contracting Authority has received funding for an automated biosensor for single-cell Interaction Cytometry. The instrument allows kinetic characterisation of molecules binding to membrane targets in individual cells. Equipment to be procured must be capable of enabling real-time kinetic binding analysis at the single-cell level, with unmatched sensitivity, microfluidic control, and fluorescence detection in a single high-throughput format. The dynamic chip-based biosensor system identified was used in the application for funding and contains patented technology (WO/2021/239855) relating to the time-resolved dynamics measurement of biosensor probes. As such, this contract shall be awarded under Regulation 33 (1) (b) (ii) as the University intends to award this public contract following the negotiated procedure without prior publication of a contract notice as the competition is absent for technical reasons.

Other Information

** PREVIEW NOTICE, please check Find a Tender for full details. ** It should be noted that this VEAT notice is intended to inform the market of the intention to award a contract under Regulation 33 (1) (b) (ii) and whilst the system requires an award date before the notice publication for the avoidance of doubt it should be noted that the contract has not been entered into before the publication of this notice. The University intend to enter into the contract on 14/07/2025. NOTE: To register your interest in this notice and obtain any additional information please visit the Public Contracts Scotland Web Site at https://www.publiccontractsscotland.gov.uk/Search/Search_Switch.aspx?ID=801360. (SC Ref:801360)