Supply and Installation of PhysioMimix OOC Multi-OrganFull System

Concepts

• birmingham
• multi-tissue system
• multi-organ interaction and disease modelling
• physiomimix ooc multi-organfull system
• the physiomimix® multi-tissue system
• system
• physiomimix
• organfull
• ooc
• project types

Location

Description

The PhysioMimix® Multi-Tissue System is particularly well suited for use in a core facility (Birmingham Tissue Analytics), where flexibility and broad applicability are key. Its modular design allows different organ models to be easily configured and reconfigured to suit a range of project needs-from single-organ toxicity studies to multi-organ interaction and disease modelling. With standardized protocols and user-friendly operation, it supports consistent, high-quality data generation across diverse applications, making it an efficient and adaptable platform for multiple research groups and project types.

Award Detail

CPV Codes

• None found

Legal Justification

The PhysioMimix® Multi-Tissue System offers a highly advanced, solution for modelling systemic human biology in vitro. By enabling the dynamic co-culture of multiple organ models-such as liver, gut, and lung-within a single, perfused microphysiological system, it provides a unique opportunity to assess inter-organ interactions, drug metabolism, distribution, and toxicity in a more integrated and human-relevant context. Product features include an open-well consumable plate design, media is pneumatically pumped recirculated through microfluidics within these plates to perfuse tissue cultures. Modular PhysioMimix® hardware consists of a Controller, Docking Station(s), and MPS driver(s), and consumable plates controlled via proprietary software. This is underpinned by patents exclusively licensed from MIT to CN Bio. This system is particularly valuable for studying drug pharmacokinetics and pharmacodynamics (PK/PD) across tissues, evaluating how metabolites formed in one organ (e.g., liver) influence the function or toxicity of others. Such capability is crucial for understanding off-target effects, bioactivation pathways, and multi-organ toxicity that are often missed in single-organ or animal models.

Other Information

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